Effect of respirator with R95 activated carbon for reducing the breath-in of oxidative product / 中国医学装备

ABSTRACT

Objective:To investigate whether respirator with R95 activated carbon could reduce the intake of polycyclic aromatic hydrocarbon (PAH) so as to analyze the effect of respirator with R95 activated carbon in reducing the breath-in of oxidative product.Methods: 44 subjects were divided into wearing respirator group (22 cases) and un-wearing respirator group (22 cases). The experiment period was 2d, and the gas chromatographic method and (or) high resolution mass spectrum were adopted to detect hydroxy PAH(OH-PAH).Results:In 44 subjects, the ratios of taxi driver was 38.6% and street hawker was 34.1%, respectively. In urine, the corrected level of baseline creatinine of 1-OHP concentration was higher than that of international standards 1020 ng/g creatinine (IQR 604-1551). Whether wearing respirator with R95 activated carbon didn't has significant effect on 1-OHP level, and its multiplier effect was 1.00 (95% CI 0.92-1.09). Besides, it also didn't has significant effect on other OH-PAHs except 1-OHN, and its multiplier effect was 0.86 (95% CI 0.77-0.96).Conclusion: In street workers, the OH-PAHs level in urine was higher. In the area with severe air pollution, wearing respirator with R95 activated carbon don't influence the OH-PAH level in urine except 1-OHN. The reasons might be respirator with R95 activated carbon couldn't efficiently filter PAHs. Besides, the OH-PAHs of high concentration indicates that it is necessary to adopt effective intervention.