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High-risk human papillomavirus genotype distribution and attribution to cervical cancer and precancerous lesions in a rural Chinese population / 부인종양
Article de En | WPRIM | ID: wpr-61160
Bibliothèque responsable: WPRO
ABSTRACT
OBJECTIVE: To explore the genotype distribution of high-risk human papillomavirus (HR-HPV) and its attribution to different grades of cervical lesions in rural China, which will contribute to type-specific HPV screening tests and the development of new polyvalent HPV vaccines among the Chinese population. METHODS: One thousand two hundred ninety-two subjects were followed based on the Shanxi Province Cervical Cancer Screening Study I (SPOCCS-I), and screened by HPV DNA testing (hybrid capture® 2 [HC2]), liquid-based cytology (LBC), and if necessary, directed or random colposcopy-guided quadrant biopsies. HPV genotyping with linear inverse probe hybridization (SPF10-PCR-LiPA) was performed in HC2 positive specimens. Attribution of specific HR-HPV type to different grades of cervical lesions was estimated using a fractional contribution approach. RESULTS: After excluding incomplete data, 1,274 women were included in the final statistical analysis. Fifteen point two percent (194/1,274) of women were HR-HPV positive for any of 13 HR-HPV types (HPV16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 68) and the most common HR-HPV types were HPV16 (19.1%) and HPV52 (16.5%). The genotypes most frequently detected in HR-HPV-positive cervical intraepithelial neoplasia grade 1 (CIN1) were HPV52 (24.1%), HPV31 (20.7%), HPV16 (13.8%), HPV33 (13.8%), HPV39 (10.3%), and HPV56 (10.3%); in HR-HPV-positive cervical intraepithelial neoplasia grade 2 or worse (CIN2+): HPV16 (53.1%), HPV58 (15.6%), HPV33 (12.5%), HPV51 (9.4%), and HPV52 (6.3%). HPV52, 31, 16, 33, 39, and 56 together contributed to 89.7% of HR-HPV-positive CIN1, and HPV16, 33, 58, 51, and 52 together contributed to 87.5% of CIN2+. CONCLUSION: In summary, we found substantial differences in prevalence and attribution of CINs between different oncogenic HPV types in a rural Chinese population, especially for HPV16, 31, 33, 52, and 58. These differences may be relevant for both clinical management and the design of preventive strategies.
Sujet(s)
Mots clés
Texte intégral: 1 Indice: WPRIM Sujet Principal: Biopsie / Dysplasie du col utérin / Tumeurs du col de l'utérus / Chine / Dépistage de masse / Prévalence / Asiatiques / Vaccins contre les papillomavirus / Tests de détection de l'ADN du virus du papillome humain / Génotype Type d'étude: Etiology_studies / Prevalence_studies / Screening_studies Limites du sujet: Female / Humans Pays comme sujet: Asia langue: En Texte intégral: Journal of Gynecologic Oncology Année: 2017 Type: Article
Texte intégral: 1 Indice: WPRIM Sujet Principal: Biopsie / Dysplasie du col utérin / Tumeurs du col de l'utérus / Chine / Dépistage de masse / Prévalence / Asiatiques / Vaccins contre les papillomavirus / Tests de détection de l'ADN du virus du papillome humain / Génotype Type d'étude: Etiology_studies / Prevalence_studies / Screening_studies Limites du sujet: Female / Humans Pays comme sujet: Asia langue: En Texte intégral: Journal of Gynecologic Oncology Année: 2017 Type: Article