Role and regulation of SPLUNC1 in respiratory tract infection / 国际儿科学杂志

ABSTRACT

Respiratory tract and the external environment are interlinked,long-term exposure to a variety of physical and chemical substances and pathogenic microorganism stimulation,the antimicrobial activity of proteins secreted by epithelial cells is critical for maintaining health.short palate,lung,and nasal epithelium clone 1 (SPLUNC1) is a lately discovered protein with antibacterial activity.Its structure is similar to the bactericidal permeability-increasing protein(BPI).SPLUNC1 binds specifically to lipopolysaccharide(LPS) of cell walls of gram-negative bacteria,and contributes to maintain homeostasis and a sterile environment in the lung,and acts as a goalkeeper role in the rapid activation of innate immunity and the initiation of adaptive immunity.SPLUNC1 is expected to become an antimicrobial agents for the treatment of respiratory tract bacterial infectious diseases.