The research progress for the role of reactive oxygen species in the occurrence of noise-induced hearing loss / 医学研究生学报

ABSTRACT

Noise-induced hearing loss (NIHL) is defined by a strong noise exposure led up the hair cells to damage which caused sensorineural hearing loss.The occurrence of NIHL is mainly related to oxidative damage, such as reactive oxygen species.Oxidative damage is mainly related to the ROS produced by noise exposure which can cause cochlear ischemia, hypoxia, and mitochondrial damage, resulting in hair cell death, further led to hearing loss.Prevention or treatment measures of NIHL is to reduce the formation of ROS and the removal of ROS.Antioxidants have been used in clinical treatment.This article reviews the effects of reactive oxygen species in NIHL to further explore the pathogenesis and prevention or treatment measures of NIHL.