Significance of Serum Testosterone for Prostate-Specific Antigen (PSA) Elevation and Prediction of Prostate Cancer in Patients with PSA Above 10 ng/ml
Korean Journal of Urology
;
: 831-835, 2010.
Article
Dans Anglais
| WPRIM
| ID: wpr-61773
ABSTRACT
PURPOSE:
Testosterone is essential for the prostate gland's normal growth and development and is also a possible risk factor for prostate cancer. This study's aim was to determine the significance of serum testosterone for prostate-specific antigen (PSA) elevation and prostate cancer prediction in high-risk men. MATERIALS ANDMETHODS:
The study included 120 patients with PSA >10 ng/ml who underwent a transrectal-prostate biopsy. Serum testosterone, prostate volume, and PSA density (PSAD) were checked in all patients. Patients were divided into two groups, patients with and those without prostate cancer; and testosterone-related factors, prostate volume, PSA, PSAD, age, prostate cancer prediction rate, and cancer aggressiveness were evaluated.RESULTS:
Thirty-five patients (30.2%) were confirmed as having prostate cancer. The average serum testosterone level in patients without and in those with prostate cancer was 452.25+/-154.62 ng/dl and 458.10+/-158.84 ng/dl, respectively; average PSA was 17.58+/-9.02 ng/ml and 18.62+/-6.53 ng/ml, respectively; and average age was 69.02+/-7.52 years and 70.69+/-7.02 years, respectively (p>0.05). Hypogonadal and eugonadal patients showed no significant difference in cancer prevalence (30.3% vs. 32.0%, respectively). The testosterone level did not differ significantly in patients with and those without prostate cancer in either hypogonadal or eugonadal men (p>0.05). Serum testosterone showed no correlation with PSA, PSAD, or age in either group (p>0.05) and was unrelated to prostate cancer risk or aggressiveness (p>0.05).CONCLUSIONS:
In our study's results, serum testosterone at the time of diagnosis was unrelated to PSA elevation, prostate cancer risk, and aggressiveness.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Prostate
/
Tumeurs de la prostate
/
Testostérone
/
Biopsie
/
Prévalence
/
Facteurs de risque
/
Antigène spécifique de la prostate
/
Croissance et développement
Type d'étude:
Etude d'étiologie
/
Étude de prévalence
/
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Korean Journal of Urology
Année:
2010
Type:
Article
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