Effect of fusidic acid on bilirubin level in neonates and infants / 中国感染与化疗杂志

ABSTRACT

Objective To examine the change of bilirubin level in neonates and infants after administration of fusidic acid.Methods The data of serum bilirubin,alanine aminotransferasese (ALT),aspartate aminotransferase (AST) and adverse drug reaction were collected retrospectively in neonates and infants and compared statistically before and after administration of fusidic acid.Results Emerging jaundice or exacerbation of the existing jaundice was not found in all the 138 patients after administration of fusidic acid in this analysis.Biochemical markers were measured before and after use of fusidic acid in 64 of the patients.ALT,AST and albumin did not show significant difference before and after use of fusidic acid.However,the ratio between indirect bilirubin and total bilirubin decreased by about 8％ after use of fusidic acid.Conclusions Fusidic acid did not show significant effect on serum bilirubin level in the neonates and infants following fusidic acid treatment.