Efficacy of cimetidine combined with acyclovir in treatment of children with varicella / 药物评价研究

ABSTRACT

Objective To discuss the efficacy ofcimetidine combined with acyclovir in treatment of children with varicella.Methods 80 cases ofvaricella were randomly divided into two groups.The observation group (40 cases) was treated with cimetidine combined with acyclovir treatment.The control group (40 cases) was given the acyclovir.Observe and record the two groups of children with clinical efficacy,fever time,rash scab,itching disappeared time after treatment,before and after treatment during the HAMA score and the treatment of adverse reactions.The clinical curative effect of cimetidine combined with acyclovir in treatment of children with varicella was evaluated.Results The observation group of total effective rate was 87.5％.The control group of total effective rate was 65％.The total effective rate of observation group was higher than the control group,the difference was statistically significant (P ＜ 0.05).After treatment,the fever time,skin rash,scab time and pruritus disappeared in the observation group were shorter than those in the control group,the difference was statistically significant (P ＜ 0.05).Before treatment,there was no statistical difference in HAMA scores between the two groups.After treatment,the scores of HAMA in the two groups were significantly lower than those in the same group before and after treatment (P ＜ 0.05),and the treatment group was significantly lower than the control group,the difference was statistically significant (P ＜ 0.05).There was no significant difference in adverse reactions between the two groups during the treatment.Conclusion Cimetidine combined with acyclovir have a good therapeutic effect on varicella.They can rapidly improve the clinical symptoms of pediatric varicella,reduce anxiety with high safety.It is worthy of clinical use.