Meta-analysis of Association between Irinotecan-induced 3-4 Degree Neutropenia and UGT1A1 Gene Poly-morphism / 中国药房
China Pharmacy
;
(12): 2523-2528, 2017.
Article
Dans Chinois
| WPRIM
| ID: wpr-619862
ABSTRACT
OBJECTIVE:
To evaluate the association between UGT1A1 gene polymorphism and irinotecan-induced 3-4 degree neutropenia,and to provide evidenced-based reference for clinical treatment.METHODS:
Retrieved from CJFD,Wanfang data-base,VIP,PubMed,EMBase,Science direct and Cochrane library,related studies about UGT1A1*28 and UGT1A1*6 gene polymorphism and irinotecan-induced 3-4 degree neutropenia were collected. After data extraction and quality evaluation of included studies,Meta-analysis was conducted by using Review Man 5.3 software.RESULTS:
A total of 29 studies were included,involv-ing 2408 patients. UGT1A1*28 includ wild genotype TA 6/6(UGT1A1*1/*1)and mutations genotype TA 6/7(UGT1A1*1/*28)、TA 7/7(UGT1A1*28/*28),UGT1A1*6 includ wild genotype GG and mutations genotype GA、AA. Results of Meta-analysis showedthe incidence of 3-4 degree neutropenia in UGT1A1*28 and UGT1A1*6 mutations genotype were significantly higher than wild genotype,with statistical significance [UGT1A1*28OR=1.92,95%CI(1.52,2.44),P<0.001;UGT1A1*6OR=2.49, 95%CI(1.46,4.26),P<0.001]. Using medium-dose and high-dose of irinotecan,the incidence of 3-4 degree neutropenia in UGT1A1*28 and UGT1A1*6 mutations genotype were significantly higher than wild genotype,with statistical significance [UGT1A1*28OR=2.06,95%CI(1.57,2.70),P<0.001);UGT1A1*6OR=1.92,95%CI(1.35,2.74),P<0.001]. Using low-dose of irinotecan,there was no statistical significance in the incidence of 3-4 degree neutropenia between UGT1A1*28,UGT1A1*6 mutations genotype and wild genotype [UGT1A1*28OR=1.20,95%CI(0.70,2.08),P=0.51;UGT1A1*6OR=3.19,95%CI (0.85,11.89),P=0.08].CONCLUSIONS:
Using medium-dose and high-dose of irinotecan,UGT1A1*28 and UGT1A1*6 muta-tions will increase the risk of severe neutropenia in cancer patients. Using low-dose of irinotecan,there is no clear correlation be-tween gene polymorphism and the neutropenia.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Type d'étude:
Revues systématiques évaluées
langue:
Chinois
Texte intégral:
China Pharmacy
Année:
2017
Type:
Article
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