Effectof Shenfuqing injection combined with glucocorticoidon the treatment of septic shock / 中国生化药物杂志

ABSTRACT

Objective To observe the effect of Shenfuqing injection combined with glucocorticoidonthe treatment of septic shock.Methods 93 cases from October 2013 to June 2015 were randomly divided into the observation group(47 cases) and the control group(46 cases).On the basis of anti infection, the observation group were given Shenfu injection combined with green glucocorticoid, and the control group were given glucocorticoid.Acute physiology and chronic health evaluation (APACHE-II score), down calcium original (PCT), high-sensitivity C-reactive protein (hs-CRP), interleukin-10 (IL-10), interleukin-1 (IL-1), interleukin-6 (IL-6), and effect in the two groups were followed-up and compared.Results APACHE-II score, PCT respectivelywere(41.69±6.25)points and (3.01±0.73)ng/mL, which were lower than (52.19±7.06) points and (4.52±1.04)ng/mL in the control group, and the difference is significant (P<0.05).hs-CRP and IL-10 were(16.38±2.45)mg/L and (26.08±3.34)pg/mL in the observation group, which were lower than (21.69±3.02)mg/L and (32.18±4.17)pg/mL in the control group, the difference was significant (P<0.05).IL-1 and IL-6 were (6.49±2.00)ng/Land (15.62±5.67)pg/mL in the observation group, which were lower than (10.45±2.26)ng/L and (26.19±7.02) pg/mLin the control group, and the difference was significant (P<0.05).The total effective rate was 74.47%, which was significantly lower than 52.17% in the control group, and the difference was significant (P<0.05).Conclusion It which Shenfuqing injection combined with glucocorticoid was use in the treatment of septic shock can significantly reduce the inflammatory factors, relieve symptoms.