Wound healing activity of Ullucus tuberosus, an Andean tuber crop
Asian Pacific Journal of Tropical Biomedicine
;
(12): 538-543, 2017.
Article
Dans Chinois
| WPRIM
| ID: wpr-620776
ABSTRACT
Objective:
This study was designed to investigate the wound healing activity of aqueous extracts of Ullucus tuberosus (U. tuberosus) using in vitro models.Methods:
Lyophilized pulp and acetone extracts of U. tuberosus were produced using ultrasound extraction. The capacity for collagenase activation was evaluated using fluo-rescence detection of the enzymatic activity. Then, the influence of U. tuberosus extracts on cell proliferation, cell migration and synthesis of the extracellular matrix (ECM) proteins, metalloproteinase (MMP-1) and pro-collagen was analyzed using human dermal fibroblasts in culture.Results:
An increase in collagenase activity of 12%supports the utility of U. tuberosus as an agent for scar treatment. In addition, the extracts showed an increase in the pro-liferation and migration of human dermal fibroblasts and the production of pro-collagen and MMP-1 after treatment with U. tuberosus extracts. The increase in proliferation, migration and pro-collagen levels positively influenced the regeneration of scarless tissue during the proliferation phase, whereas the increase in MMP-1 may have favored the wound healing process during the remodeling and cellular differentiation phases.Conclusion:
The results of this study show for first time that U. tuberosus is a promising candidate to support scarless tissue regeneration.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Asian Pacific Journal of Tropical Biomedicine
Année:
2017
Type:
Article
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