Expression and clinical significance of C1orf63 in breast cancer / 国际肿瘤学杂志
Journal of International Oncology
; (12): 420-422, 2017.
Article
Dans Zh
| WPRIM
| ID: wpr-620957
Responsable en Bibliothèque :
WPRO
ABSTRACT
Objective To investigate the expression and clinical significance of C1orf63 in breast cancer.Methods Sixty-seven breast cancer tissues and adjacent non-cancerous tissues were collected,and the expression of C1orf63 was detected by immunohistochemistry.The relationships between C1orf63 and clinical pathological characteristics were examined withx2 test.Independent prognostic factors were performed by theCox regression model.Results Positive cytoplasmic expression of C1orf63 was observed in 21 (31.3%) of 67 primary tumors,but not in their matched adjacent non-cancerous tissues,with significant difference (x2 =24.90,P < 0.01).There were no relationships between C1orf63 and age (x2 =0.06,P =0.79),T stage (x2 =0.50,P =0.47),N stage (x2 =1.41,P =0.23),TNM stage (x2 =0.29,P =0.58),estrogen receptor (x2=0.82,P =0.36),progesterone receptor (x2=0.31,P =0.57),and human epidermal growth factor receptor 2 (Her2) expression (x2 =0.00,P =0.98).Multivariate analysis demonstrated N stage (HR =4.96,95%CI:2.03-12.15,P<0.01) and C1orf63 (HR=2.37,95%CI:1.05-5.37,P=0.04) were unfavorable prognostic factors.Conclusion The high expression of C1orf63 in breast cancer may indicate poor prognosis.
Texte intégral:
1
Indice:
WPRIM
Type d'étude:
Prognostic_studies
langue:
Zh
Texte intégral:
Journal of International Oncology
Année:
2017
Type:
Article