THE OVEREXPRESSION OF APOPTOSIS -RELATED GENES OF P53 AND BCL-2 IN CERVICAL CARCINOMA / 药物分析学报

ABSTRACT

Objective To investigate the significance of overexpression of P53 and bcl-2 protein in carcinogenesis of cervix. Methods 10 cases of cervical intraepithelial neoplasis(CIN) and 57 cases of invasive cancer were investigated with immunohistochemistry technique. Results The overexpresion of P53 protein in CIN and cervical cancer was significantly higher than that of control, respectively (P＜0.01). But there was no significant difference between CIN and cervical cancer(P＞0. 05). The immunoreactivity of bcl-2 in CIN was much more higher than that of control (P＜0.05). The positive rate and immunoreactivity of bcl-2 in cervical carcinoma were both remarkably higher than those of control (P＜0. 01) ,but there was no significant difference between CIN and cervical carcinoma (P＞0. 05). It was also found that there was a remarkably positive correlation between the overexpression of bcl-2 and P53 (P＜0.01). Conclusion Because of the loss of wtP53 function,the expression of bcl-2 can not be down-reguated,which is associated with the pathogenesis and development of cervical carcinoma.