Lymphatic vessel density and lymphatic metastasis in gastroduodenal neuroendocrine carcinoma / 中华内分泌外科杂志

ABSTRACT

Objective To investigate the relationship of lymphatic vessel density (LVD)and lymphatic metastasis in gastroduodenal neuroendocrine carcinoma.Methods The intratumor lymphatic vessel deusity(iLVD) and peritumor lymphatic vessel density(pLVD) of 55 surgical gastroduodenal neuroendocrine carcinoma tissue samples were detected by immunohistochemistry(with monoclona1 antibody D2-40).The relationship of lymphatic metastasis and pLVD,iLVD was analyzed.Results The value of pLVD and iLVD was 31.02 ± 1.22 vs 5.29 ± 0.76 for gastroduodenal neuroendocrine carcinoma with lymph node metastasis,while it was 20.43 ± 1.39 vs 5.64 ± 1.01 for gastroduodenal neuroendocrine carcinoma without lymph node metastasis,showing pLVD was significantly higher than iLVD in both groups.pLVD of gastroduodenal neuroendocrine carcinoma was closely related to lymph node metastasis (P =0.001,r =0.872),the differentiation of carcinoma,and lymphatic involvement while iLVD of gastroduodenal neuroendocrine carcinoma had no relation with lymph node metastasis(P =0.293).Conclusion Compared to iLVD detection,pLVD detection is more valuable in gastroduodenal neuroendocrine carcinoma since it can help to predict lymph node metastasis status and the prognosis.