High In Vitro Infectivity of a Doxycycline-Insensitive Strain of Orientia tsutsugamushi / 감염과화학요법
Infection and Chemotherapy
;
: 431-434, 2013.
Article
Dans Anglais
| WPRIM
| ID: wpr-62686
ABSTRACT
We compared the infectivity and growth rates of 12 strains of Orientia tsutsugamushi in a cell culture system. ECV304 cells were infected with O. tsutsugamushi strains for 4 hr, and the culture was maintained for 72 hr. Immunofluorescence (IF) staining was performed at 4, 24, 48, and 72 hr after inoculation (hpi), and IF-positive foci were enumerated. The AFSC-4 strain, which is known to be insensitive to doxycycline, showed higher numbers of IF-positive foci than the other 11 strains at 4, 24, 48, and 72 hpi, which may explain its apparent insensitivity to antibiotics.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Orientia tsutsugamushi
/
Virulence
/
Résistance aux substances
/
Fièvre fluviale du Japon
/
Technique d'immunofluorescence
/
Doxycycline
/
Techniques de culture cellulaire
/
Antibactériens
langue:
Anglais
Texte intégral:
Infection and Chemotherapy
Année:
2013
Type:
Article
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