Isobolographic Analysis of the Hypnotic Interaction Between Propofol and Thiopental
Malaysian Journal of Medicine and Health Sciences
;
: 83-89, 2010.
Article
Dans Anglais
| WPRIM
| ID: wpr-628025
ABSTRACT
Introduction:
Giving two intravenous anaesthetic agents simultaneously generally results in an additive effect. The aim of this study was to investigate the interaction between propofoland thiopental when given to patients who have had sedative premedication.Methods:
Fifty patients were admitted into the study. All patients received oral midazolam 3.75mg and intravenous fentanyl 100mg before induction of anaesthesia. Twenty patients received an infusion of their propofol or thiopental while 30 patients received an infusion of an admixture of both drugs.Results:
The interaction between propofol and thiopental was additive. The average dose at loss of the eyelash reflex for propofol and thiopental was 0.71mg kg-1 and 1.54mg kg-1 respectively. Premedication decreased the induction dose by 38.2%.Conclusion:
Propofol and thiopental interact in an additive fashion when given at induction of anaesthesia
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Anglais
Texte intégral:
Malaysian Journal of Medicine and Health Sciences
Année:
2010
Type:
Article
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