The identifi cation results for the diagnostic sensitivity of cervical liquid based cytology testing / Монголын Анагаах Ухаан

ABSTRACT

Introduction Cervical cancer screening program is using conventional Pap smear (CPS) have been successfully used in Mongolia, but new kind of test as “Liquid based cytology” (LBC) is not popular for screening. This liquid based cytology testing might reduce the number of unsatisfactory smears, and increase the accuracy of diagnosing. Goal The main aim of this study was to assess diagnostic accuracy and sensitivity of Liquid based cytology versus Conventional Pap smear using ‘split-samples’ technique. Materials and Methods This was cross sectional study, total of 75 cervical split samples were included over a period of 2 months. Split sample was obtained using cervix-brush. CPS was prepared from brush and the brush head was suspended in the Liquid based vial and processed by LBC method and pap staining. Smears were diagnosed by cytologists. Abnormal smears were concluded by cervical biopsy as a Golden Standard. Results There were 14%unsatisfactory smears in CPS and 6% in LBC; the main cause is insuffi cient cells, and excess blood in CPS. LBC had diagnostic accuracy of LSIL was lower, but ASC-US was higher than CPS was signifi cant. LBC (100%) was more sensitive than CPS (89%) was confi rmed by biopsy. Conclusions: LBC testing was successfully reduced unsatisfactory smears rate. LBC samples offered better clarity and uniform spread of smears, less time for screening and better diagnostic accuracy of LSIL and ASC-US than CPS.