Daily intake of hexachlorobenzene with food, oral exposure and health risk / Монголын Анагаах Ухаан

ABSTRACT

Background. Persistent organic pollutants include pesticides such as aldrin,dieldrin, endrin, chlordane, heptachlor, hexachlorobenzene, mirex, toxaphene, polychlorinated biphenyls, dioxins, furans. Hexachlorobenzene has been used on timber and unnatural rubber. It has also been used for the preparation of paints and ammunition. HCB is a fungicide for cereals, onion and wheat, and also a byproducts of the pesticide manufacturing process. During the past four decades, great concern and considerable attention have been given to the toxic effects of the hexachlorobenzene that eliminated or restricted the production, use, import and export by the Stockholm convention. The aim of this work is to estimate a dietary intake of hexachlorobenzene with some food by a general population in Mongolia. Goal The goal of this study is to estimate a dietary intake of hexachlorobenzene with some food by a general population in Mongolia which eliminated or restricted the production, use, import and export in the worldwide by the Stockholm Convention and to assess an oral exposure and health risk. Objectives: 1. To determine concentrations residue of hexachlorobenzene in vegetables, fruits and in rice. 2. To estimate a dietary intake of hexachlorobenzene with some vegetables, fruits and rice by a general population in Mongolia 3. To estimate the oral Reference Dose of hexachlorobenzene as units of mg/kg-day in body weight. Results: Total quantity of fungicides imported to Mongolia in 2007 was about 4.087 l. Residue of hexaclorobenzene was detected in potatoes, vegetables ranging from 0.12 to 0.16 mg/kg, in fruits 0.66 mg/kg, and in rice 0.25-mg/kg. The intake of HCBz in men was estimated at about 0.17806 mg, and in women 0.05791 mg, respectively. The oral Reference Dose of HCBz was estimated 0.0026 mg in per kilogram of body weight in Mongolian men and 0.00094 mg in per kilogram of body weight in Mongolian women per day. The intake of HCBz were estimated about at 0.17196 mg in children aged 1-3 years, 0.13954 mg in children aged 4-6 years, 0.18596 mg in children aged 7-10 years, and 0.18596 mg in children of aged 11-14 years. The oral reference Dose of HCBz was estimated about at 0.17196 mg in per kilogram of the body weight of children aged 1-3 years and 0.13954 mg in per kilogram of the body weight of children aged 4-6. Also the oral reference dose of HCBz were estimated 0.13954 mg in per kilogram of the body weight of children aged 7-10 years while 0.18596 mg in per kilogram of the body of children aged 11-14 years per day. Conclusions: 1. Hexachlorobenzene is being imported to Mongolia which eliminated or restricted the production, use, import and export. 2. Potatoes, vegetables, fruit and rice were contained residues of hexachlorobenzene. 3. The oral reference Dose of HCB was reached to liver effects dose in 0.0008 mg/kg day.