Association of coronary flow reserve by dipyridamole technetium-99m sestamibi single photon emission computed tomography with perfusion findings and risk factors for coronary artery disease
The Philippine Journal of Nuclear Medicine
;
: 8-14, 2015.
Article
Dans Anglais
| WPRIM
| ID: wpr-632930
ABSTRACT
BACKGROUND:
Blunting of coronary flow reserve (CFR) may precede overt ischemia. The study aimed to correlate CFR with perfusion findings and risk factors for coronary artery disease (CAD).METHODS:
Fifty-four consecutive patients underwent dipyridamole-rest technetium-99m sestamibi single photon emission computed tomography (SPECT) on two separate days. CFR was computed as the quotient of myocardial blood flow (MBF= global tissue perfusion divided by arterial input function) at stress and at rest.RESULTS:
CFR was significantly lower in patients with abnormal perfusion vs normals (p=0.005). Reduced CFR was noted in 83% of patients with normal SPECT. Lower CFR was seen in hypertensive patients with left ventricular hypertrophy (LVH) compared to those without LVH (p=0.029); likewise in DM vs no DM (p=0.121). Independent predictors of reduced CFR were age and extent of ischemia.CONCLUSION:
Abnormal perfusion is associated with reduced CFR. In those with normal perfusion, there is a high prevalence of reduced CFR, which may be attributed to the presence of risk factors for CAD and LVH.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Artères
/
Maladie des artères coronaires
/
Tomographie par émission monophotonique
/
Facteurs de risque
/
Technétium (99mTc) sestamibi
/
Hypertrophie ventriculaire gauche
/
Dipyridamole
Type d'étude:
Etude diagnostique
/
Etude d'étiologie
/
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
The Philippine Journal of Nuclear Medicine
Année:
2015
Type:
Article
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