Possible Local Stem Cells Activation by Microcurrent Application in Experimentally Injured Soleus Muscle
International Journal of Stem Cells
;
: 79-86, 2014.
Article
Dans Anglais
| WPRIM
| ID: wpr-63298
ABSTRACT
BACKGROUND:
Severe injuries in skeletal muscle result in muscle weakness that delays recovery and contribute to progressive decline in muscle function. Microcurrent therapy (MCT) is a novel treatment method used in soft tissue injury and tissue regeneration therapy. The regenerative capacity of skeletal muscle tissue resides in satellite cells, the quiescent adult stem cells.AIM:
The present work aimed at investigating the relation between microcurrent therapy and local stem cells in regeneration of induced skeletal muscle injury in albino rat. MATERIALS ANDMETHODS:
Twenty six adult male albino rats were divided into Sham group, Injury group (I) subjected to soleus muscle injury and subdivided into subgroups I1 & I2 sacrificed 2 and 4 weeks after injury respectively. Microcurrent group (M) subjected to muscle injury and micro-current was applied. The animals were subdivided into subgroups M1 and M2 sacrificed 2 and 4 weeks after injury. Histological, immunohistochemical and morphometric studies were performed.RESULTS:
Atypical fibers widely separated by infiltrating cells and strong acidophilic sarcoplasm with focal vacuolations were found in injury group. In M1 subgroup few atypical fibers were found. In M2 subgroup multiple typical fibers were detected. A significant decrease in the mean area of atypical fibers, a significant increase in the mean area% of alpha SMA+ve cells and that of CD34+ve cells were found in microcurrent group compared to injury group.CONCLUSIONS:
A definite therapeutic effect of the microcurrent was found on induced skeletal muscle injury. This effect was proved to be related to satellite cell activation.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Régénération
/
Cellules souches
/
Traumatismes des tissus mous
/
Muscles squelettiques
/
Faiblesse musculaire
/
Cellules souches adultes
/
Neurofibres myélinisées
Limites du sujet:
Animaux
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
International Journal of Stem Cells
Année:
2014
Type:
Article
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