Generalized asymptomatic red nodules in a 21-year old Filipino male
Journal of the Philippine Dermatological Society
;
: 71-73, 2008.
Article
Dans Anglais
| WPRIM
| ID: wpr-632987
ABSTRACT
A 21 year old Filipino male presented with swelling of the second right hand digit unresponsive to antibiotics. Amputation revealed chronic inflammation and negative cultures. He developed sterile conjunctivitis and a generalized eruption of asymptomatic red papules and nodules. First skin biopsy revealed a diffuse infiltrate of epithelioid and foamy histiocytes, diagnosed as "juvenile xanthogranuloma." The second biopsy revealed large histiocytes with a "ground-glass" eosinophilic cytoplasm, multinucleated giant cells, and mixed cell infiltrate. Immunohistochemistry showed histiocytes staining with (+)S100 and (+)CD68, and (-)CD1a. Final diagnosis was "multicentric reticulohistocytosis." Despite treatment with oral prednisone, methotrexate and alendronate, lesions were progressive. CONCLUSION:
This fascinating case manifests with overlapping features of both juvenile xanthogranuloma and multicentric reticulohistiocytosis, and lead the authors to suggest considering the spectrum of diseases called the non-Langerhans cells histiocytosis when presented with a generalized nodular eruption.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Biopsie
/
Cellules géantes
/
Histiocytose non langerhansienne
/
Méthotrexate
/
Conjonctivite
/
Antigènes CD1
/
Exanthème
/
Histiocytes
/
Inflammation
Limites du sujet:
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Journal of the Philippine Dermatological Society
Année:
2008
Type:
Article
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