Dysgenesis of the corpus callosum presenting as first-onset seizures in an apparently normal 32-year-old female

ABSTRACT

INTRODUCTION: Dysgenesis of the corpus callosum is a brain abnormality  involving  the  large  nerve  fibers  connecting  the  two  hemispheres  of  the  brain.  The  corpus  callosum  connects  the  left  and  right  cerebral  hemispheres  and  facilitates  interhemispheric  communication.  When it is malformed, these functions might be affected. CLINICAL PRESENTATION This case report documents a patient with a malformed corpus callosum. She came in for first-onset generalized tonic clonic seizures. As part of a routine workup  for  patients  with  first-onset  seizures,a computed tomography (CT) scan of the brain was done. It revealed dysgenesis  of  the  corpus  callosum.  She  was  started on valproic acid and was discharged improved. CONCLUSION: Callosal disorders  usually present with some degree of neurologic impairment. The index case however has  no  detectable  neurologic  deficits  and  is  apparently normal.  The  rarity  of  a  dysgenetic  corpus  callosum mandates more epidemiological studies to further elucidate this disease.