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A meta-analysis of operative effectiveness of trabeculectomy combined with amniotic membrane implant for glaucoma / 中华实验眼科杂志
Chinese Journal of Experimental Ophthalmology ; (12): 275-281, 2013.
Article Dans Chinois | WPRIM | ID: wpr-636021
ABSTRACT
Background Many methods are widely studied to improve the therapeutic effect of trabeculectomy for glaucoma,and the clinical effectiveness of the amniotic membrane application during trabeculectomy is one of the research hotspots.Objective This study was to evaluate the efficacy and safety between trabeculectomy with (TE-AMT) and without amniotic membrane transplantation (TE-noAMT) for treating glaucoma.Methods Articles published from 1965 to December 2010 were searched from The Cochrane Library,PubMed,EMBASE,CNKI,Chinese Biomedicine Database,internet by computer,and manual search then was performed according to the predetermined strategy.Randomized controlled trials (RCT) on TE-AMT and TE-noAMT were included.The quality of included articles were scored based on Jadad table,and the relative parameters and information were extracted,including author,design of the trials,country,number of eyes and patients,gender,follow-up duration,age,classification of glaucoma,baseline IOP and loss rate.The main analysis indicators were the percentage of IOP reduction,completely operative successful rate,qualified success rate and adverse events.The pooled estimates were carried out with RevMan version 5.0 software.Results Nineteen RCTs documents were reviewed by meta-analysis with the Jaded scores ≥3 in 2 papers and <3 in 17 papers.Total 977 eyes of 818 patients were included.The weighted mean differences (WMD) of the percentage of IOP from baseline were (WMD =8.47%,95% CI5.20-11.75) at 6 months and (WMD=9.37%,95% CI4.97-13.77) at 12 months postoperatively.Relative risk (RR) of complete success rate and qualified success rate at postoperative 6 months were (1.40,95% CI1.19-1.65) and (0.47,95% CI0.22-1.00),respectively.RR values of adverse event such as shallow anterior chamber,hyphema,hypotony and choroidal detachment,failed filtering blebs at 6,12 months were 0.51 (95 % CI0.30-0.85),0.43 (95% CI0.20-0.92),0.51(95%CI0.26-1.00) and 0.57(95%CI0.14-2.31),0.31(95%CI0.20-0.47),0.31 (95% CI0.17-0.55),respectively.Conclusions TE-AMT appears to have better efficacy in lowering IOP,increasing complete success rate and reducing adverse event I in comparison with TE-noAMT.

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Type d'étude: Essai clinique contrôlé / Guide de pratique / Revues systématiques évaluées langue: Chinois Texte intégral: Chinese Journal of Experimental Ophthalmology Année: 2013 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Type d'étude: Essai clinique contrôlé / Guide de pratique / Revues systématiques évaluées langue: Chinois Texte intégral: Chinese Journal of Experimental Ophthalmology Année: 2013 Type: Article