Application of transplantation of microencapsulated engineered stem cells in ophthalmology / 中华实验眼科杂志

ABSTRACT

Transplantation of microencapsulated genetic engineered stem cells is a new biological approach for the treatment of many refractory diseases.Transplantation of microencapsulated genetic engineered stem cells can transfect the interest gene into the target cells and further implants the gene to host after being microencapsulated.The microcapsules improve the survival time of target cells and remain the cells to play their biological function for a longterm duration,and the microencapsulated cells present with immunoisolation and good biocompatibility after transplantation.This technology will make it possible for the xenotransplantation or gene engineered cell transplantation.Recently,transplantation of microencapsulated genetic engineered stem cells has been used in clinical trial of retinal pigment degeneration and made progress,which laid a foundation for the management of other chronic and refractory eye diseases.The concept and principle of the microencapsulation technology are outlined,and the application of gene modification of stem cells in ophthalmology are reviewed in this article.