Effect of c-fos Antisense on Neuronal Apoptosis in Rats′ Brain with Pentyleneterazol-Induced Seizure / 实用儿科临床杂志

ABSTRACT

Objective To probe the effect of c-fos gene on the pentyleneterazol-induced hippocampal neurons apoptosis.Methods Using immunohistochemistry,TUNEL and flow cytometry(FCM),we detected the Fos expression and the apoptosis of hippocampal neurons;we injected c-fos antisense into ventrile before epilepsy and detected as up.Results Epilepsy can induce the expression of Fos in the hippocampus and peaking at 1 h(P