The Effect of NK-1 Receptor Antagonist on the Enhanced Response to Bradykinin by Mustard Oil Treatment of the Rat Uterus / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology
;
: 1325-1331, 2003.
Article
Dans Coréen
| WPRIM
| ID: wpr-63891
ABSTRACT
OBJECTIVE:
To find out wheather the substance P takes part in the pain mediating system of uterus, and to ascertain the role of substance P in the hypersensitivity of hypogastric nerve to bradykinin during the uterine inflammation.METHODS:
The uterus has two sensory innervations, which are the hypogastric nerve and the pelvic nerve. Since the hypogastric nerve is known to show increased sensitivity to bradykinin, a pain mediator, when the uterus is in inflammatory state, the hypogastric nerve recording was done for electrophysiological study of uterine pain-mediating mechanism in female SD rats (200-250 g). NK1 receptor antagonist (L-703,606) was injected through uterine artery before injecting bradykinin while uterus was under inflammation.RESULTS:
The NK-1 receptor antagonist (L-703,606) decreased the spontaneous nerve impulse during inflammation, and it also decreased the hypersensitivity of the hypogastric nerve to bradykinin during the uterine inflammation.CONCLUSION:
Substance P mediates the pain sense of hypogastric nerve, and it also plays a role in increased sensitivity of hypogastric nerve to bradykinin while uterus is in inflammatory state.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Utérus
/
Potentiels d'action
/
Bradykinine
/
Substance P
/
Négociation
/
Récepteur de la neurokinine 1
/
Artère utérine
/
Hypersensibilité
/
Inflammation
/
Moutarde (plante)
Limites du sujet:
Animaux
/
Femelle
/
Humains
langue:
Coréen
Texte intégral:
Korean Journal of Obstetrics and Gynecology
Année:
2003
Type:
Article
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