Slowly Progressing Thrombotic Microangiopathy during Two Years of Treatment with Sunitinib / 대한신장학회지
Korean Journal of Nephrology
;
: 533-536, 2011.
Article
Dans Anglais
| WPRIM
| ID: wpr-64073
ABSTRACT
A 75-year-old man with mild renal impairment was started on sunitinib for a metastatic gastrointestinal stromal tumor. After 7 months of this therapy, proteinuria became aggravated. Serum creatinine concentration was increased from 1.34 to 2.57 mg/dL 24 months after sunitinib administration. Hematologic features of thrombotic microangiopathy (TMA) were absent. Renal histology revealed endothelial swelling and plasmatic insudation of the glomeruli. Proteinuria and renal function improved after discontinuation of sunitinib. Our experience suggests that TMA associated with sunitinib can be diverse in onset and severity, and that the hematologic features of TMA may be absent.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Protéinurie
/
Pyrroles
/
Créatinine
/
Facteur de croissance endothéliale vasculaire de type A
/
Tumeurs stromales gastro-intestinales
/
Microangiopathies thrombotiques
/
Indoles
Limites du sujet:
Adulte très âgé
/
Humains
langue:
Anglais
Texte intégral:
Korean Journal of Nephrology
Année:
2011
Type:
Article
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