Effect of hydroxy groups in natural flavones on ocular blood flow of rabbits and retinal function recovery after ischemia insult in rat eyes / 国际眼科杂志(Guoji Yanke Zazhi)

ABSTRACT

AIM: To determine the effect of hydroxy (OH) group on the ocular blood flow and retinal function recovery.METHODS: Colored microsphere technique was used to determine the ocular blood flow in rabbit eyes and electroretinography was used to measure the retinal function recovery.RESULTS: Flavones with four free OH groups seemed to produce the optimal effects in ocular blood flow increase and retinal function recovery. When there were 3OH groups (Apigenin), rapid increment in ocular blood flow and retinal function recovery was found. When the number of OH groups was below two (7-Hydroxyfiavone,Chrysin), no effect was observed on the ocular blood flow. The attachment of rutinose group in the fiavone (Diosmin) with two free OH groups and methoxy group did not affect the ocular blood flow or retinal function recovery, but the attachment of glucose group in the fiavone (Luteolin-7-glycoside) with catechol group affected the ocular blood flow one way or the other. The attachment of methoxy group in the fiavone (Acacetin)with two free OH groups affected ocular blood flow and retinal function recovery after ischemic insult.CONCLUSION: Ocular blood flow and retinal function recovery are increased significantly with the increase in the number of OH groups attached in the flavone molecule, with the 7-OH group and the catechol group in the B ring the most efficient to enhance the ocular blood flow and retinal function recovery after ischemic insult.