Effect of Retinoic Acid on the Expression of PDGF Receptors During Palatogenesis / 대한해부학회지
Korean Journal of Anatomy
;
: 383-392, 2006.
Article
Dans Anglais
| WPRIM
| ID: wpr-643796
ABSTRACT
Although cleft lip and palate are one of the most common craniofacial malformation, little is still known about the mechanism of the palate formation. Retinoic acid (RA) is known a teratogen, and cleft palate is induced by retinoic acid administration in the secondary palate formation stage. Many growth factors and their receptors are involved in the formation of the secondary palate. Here, we investigated the expression of PDGFR-alpha, and PDGFR-beta during palatogenesis after retinoid acid administration in mice by RT-PCR and immunohistochemistry. At E15.5, the opposing palatal shelves fused with one another in the control group, but the palatal shelves were not elevated and cleft palate was induced in the RA-treated group. In RT-PCR, PDGFR-beta was downregulated during palatogenesis after RA administration. In immunohistochemical experiment, PDGFR-alpha and PDGFR-beta were reduced in RA-induced group. Taken together, we suggest that PDGF receptors may be molecules involved in palate formation.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Palais
/
Trétinoïne
/
Immunohistochimie
/
Bec-de-lièvre
/
Fente palatine
/
Récepteurs aux facteurs de croissance dérivés des plaquettes
/
Protéines et peptides de signalisation intercellulaire
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Korean Journal of Anatomy
Année:
2006
Type:
Article
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