An Immunohistochemical Study on the Macrophages in the Developing Corpora Lutea of the Rat / 대한해부학회지
Korean Journal of Anatomy
;
: 171-177, 2007.
Article
Dans Coréen
| WPRIM
| ID: wpr-644163
ABSTRACT
Within the corpus luteum, macrophages exert luteotropic and luteolytic actions through secretion of TNF-alpha. However, the mechanisms of luteotropic actions on the development and maintenance of pregnant and nonpregnant corpora lutea are thoroughly unknown.In this experiment, TUNEL, macrophage, and TNF-alpha immunohistochemistry on the corpora lutea of pregnant and nonpregnant rats (Sprague-Dawley strain) were carried out to reveal the role of macrophages in the developing corpora lutea. The results were as follows; 1) In the nonpregnant corpora lutea, the number of macrophages was increased significantly, and the degree of ED1-immunoreactivity of macrophages was increased moderately. But lutein cells showed low-degree TNF-alpha-immunoreactivity. 2) In the pregnant corpora lutea, the number of macrophages was decreased significantly, and the degree of ED1- immunoreactivity of macrophages was low. But lutein cells showed moderate-degree TNF-alpha-immunoreactivity. Based on the above results, it was considered that macrophages in the nonpregnant corpora lutea exert phagocytic action mainly, and the macrophages in the pregnant corpora lutea exert TNF-alpha-secreting action to maintain the structure and function of lutein cells.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Immunohistochimie
/
Facteur de nécrose tumorale alpha
/
Corps jaune
/
Méthode TUNEL
/
Cellules lutéales
/
Macrophages
Limites du sujet:
Animaux
langue:
Coréen
Texte intégral:
Korean Journal of Anatomy
Année:
2007
Type:
Article
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