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Expression and Clinical Significance of Heparanasein Osteosarcoma / 대한정형외과학회잡지
The Journal of the Korean Orthopaedic Association ; : 43-51, 2006.
Article Dans Coréen | WPRIM | ID: wpr-644198
ABSTRACT

PURPOSE:

This study examined the expression of heparanase in osteosarcomas and evaluated its prognostic value. MATERIALS AND

METHODS:

The immunohistochemical expression of heparanase from 51 osteosarcoma tissues was examined, and the correlations between the heparanase expression level and the clinicopathological factors were evaluated.

RESULTS:

Heparanase over-expression was observed in 37 tissue samples. There was a correlation between the heparanase expression level and a poor chemotherapeutic response, metastasis and poor survival rate. Multivariate analyses revealed that heparanase over-expression was a significant independent risk factor for a distant metastasis of an osteosarcoma. Among the 46 patients who underwent an adequate wide resection, there was a correlation between the heparanase expression level and recurrence. The 5-year survival rate was 83.8% for patients with heparanase negative tumors, and 46.9% for those with heparanase over-expression. Multivariate analysis using the Cox regression model revealed the heparanase expression level to be an independent prognostic indicator.

CONCLUSION:

These results indicate that heparanase expression might play an important role in local recurrence and metastasis, and might be a biological marker of the prognostic significance in osteosarcoma patients.
Sujets)

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Pronostic / Récidive / Immunohistochimie / Marqueurs biologiques / Ostéosarcome / Analyse multifactorielle / Taux de survie / Facteurs de risque / Métastase tumorale Type d'étude: Etude d'étiologie / Étude pronostique / Facteurs de risque Limites du sujet: Humains langue: Coréen Texte intégral: The Journal of the Korean Orthopaedic Association Année: 2006 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Pronostic / Récidive / Immunohistochimie / Marqueurs biologiques / Ostéosarcome / Analyse multifactorielle / Taux de survie / Facteurs de risque / Métastase tumorale Type d'étude: Etude d'étiologie / Étude pronostique / Facteurs de risque Limites du sujet: Humains langue: Coréen Texte intégral: The Journal of the Korean Orthopaedic Association Année: 2006 Type: Article