Expression and Clinical Significance of Heparanasein Osteosarcoma / 대한정형외과학회잡지
The Journal of the Korean Orthopaedic Association
;
: 43-51, 2006.
Article
Dans Coréen
| WPRIM
| ID: wpr-644198
ABSTRACT
PURPOSE:
This study examined the expression of heparanase in osteosarcomas and evaluated its prognostic value. MATERIALS ANDMETHODS:
The immunohistochemical expression of heparanase from 51 osteosarcoma tissues was examined, and the correlations between the heparanase expression level and the clinicopathological factors were evaluated.RESULTS:
Heparanase over-expression was observed in 37 tissue samples. There was a correlation between the heparanase expression level and a poor chemotherapeutic response, metastasis and poor survival rate. Multivariate analyses revealed that heparanase over-expression was a significant independent risk factor for a distant metastasis of an osteosarcoma. Among the 46 patients who underwent an adequate wide resection, there was a correlation between the heparanase expression level and recurrence. The 5-year survival rate was 83.8% for patients with heparanase negative tumors, and 46.9% for those with heparanase over-expression. Multivariate analysis using the Cox regression model revealed the heparanase expression level to be an independent prognostic indicator.CONCLUSION:
These results indicate that heparanase expression might play an important role in local recurrence and metastasis, and might be a biological marker of the prognostic significance in osteosarcoma patients.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pronostic
/
Récidive
/
Immunohistochimie
/
Marqueurs biologiques
/
Ostéosarcome
/
Analyse multifactorielle
/
Taux de survie
/
Facteurs de risque
/
Métastase tumorale
Type d'étude:
Etude d'étiologie
/
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Humains
langue:
Coréen
Texte intégral:
The Journal of the Korean Orthopaedic Association
Année:
2006
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS