The Expression of p53 and PCNA in Patients with Locally Recurrent Laryngeal Cancer after Radiotherapy / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery
; : 52-55, 2004.
Article
de Ko
| WPRIM
| ID: wpr-645617
Bibliothèque responsable:
WPRO
ABSTRACT
BACKGROUND AND OBJECTIVES: The biologic changes in recurrent laryngeal cancer following radiotherapy are not fully understood. The authors investigated the expression of p53 and proliferating cell nuclear antigen (PCNA) in patients with locally recurrent laryngeal cancer after radiotherapy. MATERIALS AND METHODS: The authors investigated the expression of p53 and PCNA by immunohistochemical stain in 15 patients with recurrent laryngeal cancer after radiotherapy. RESULTS: The expression of p53 protein was significantly different between laryngeal cancer before radiotherapy (4/15, 26.7%) and recurrent laryngeal cancer after radiotherapy (8/15, 53.3%) (p<0.05). Also, PCNA index was significantly different between laryngeal cancer before radiotherapy (mean, 11.9%) and recurrent laryngeal cancer after radiotherapy (mean, 18.0%) (p<0.05). CONCLUSION: The expressions of p53 protein and PCNA were increased more in the recurrent laryngeal cancer after radiotherapy than in the laryngeal cancer before radiotherapy. Recurrent laryngeal cancers changed to biologically aggressive cancer after following radiation therapy.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Radiothérapie
/
Tumeurs du larynx
/
Gènes p53
/
Antigène nucléaire de prolifération cellulaire
Limites du sujet:
Humans
langue:
Ko
Texte intégral:
Korean Journal of Otolaryngology - Head and Neck Surgery
Année:
2004
Type:
Article