Substance P Modulates Properties of Normal and Diabetic Dermal Fibroblasts
Tissue Engineering and Regenerative Medicine
;
(6): 155-161, 2016.
Article
Dans Anglais
| WPRIM
| ID: wpr-646903
ABSTRACT
Dermal fibroblasts play essential roles in wound healing. However, they lose their normal regenerative functions under certain pathologic conditions such as in chronic diabetic wounds. Here, we show that substance P (SP) rescues the malfunctions of dermal fibroblasts in diabetes. SP increased the proliferation of diabetic dermal fibroblasts dose-dependently, although the effect was lower compared to the SP-stimulated proliferation of normal dermal fibroblasts. In contrast to normal dermal fibroblasts, SP increased the expression level of vascular endothelial growth factor (VEGF) and stromal cell-derived factor-1 (SDF-1) in diabetic dermal fibroblast hence, rescuing their angiogenic potential. The cellular characteristics of diabetic dermal fibroblasts modulated by SP would be able to accelerate the wound healing process through faster wound contraction and improved angiogenesis in diabetic chronic wounds. Moreover, SP pretreatment into dermal fibroblasts isolated from diabetic patients would be a promising strategy to develop autologous cell therapy for treating diabetic chronic wounds.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Cicatrisation de plaie
/
Plaies et blessures
/
Substance P
/
Facteur de croissance endothéliale vasculaire de type A
/
Fibroblastes
/
Thérapie cellulaire et tissulaire
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Tissue Engineering and Regenerative Medicine
Année:
2016
Type:
Article
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