Effects of Estrogen on Intracellular Calcium-Related T-Lymphocyte Function
Tissue Engineering and Regenerative Medicine
; (6): 270-273, 2016.
Article
Dans En
| WPRIM
| ID: wpr-649689
Responsable en Bibliothèque :
WPRO
ABSTRACT
Regulation of immune cell function is an important in the field of hormone-related tissue engineering and regenerative medicine. In this sense, hormonal regulation of immune cell function is a critical issue to be solved. It has been known that ovarian sex hormone play an important roles in immune function, however, little has been known whether estrogen affects T-lymphocyte function. Human Jurkat T cells were treated with estradiol (E₂) at concentrations of 0, 10, 100, 1000 ng/mL, and calcium response was evaluated. Intracellular calcium concentrations after Fura-2 acetoxymethyl ester treatment show an increasing trend at higher E₂ concentrations although these alterations did not reach a statistical significance. The expression of calcium channel-related gene CACNA1C did not show any significant changes according to the concentration of E₂. Taken together, estrogen has an implication as a possible hormonal regulator of intracellular calcium release in human Jurkat T cells via non-genomic pathway. Further studies are necessary to investigate the combined effects of sex hormones and cytokines in both T- and B-lymphocytes.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Hormones sexuelles stéroïdiennes
/
Lymphocytes B
/
Lymphocytes T
/
Canaux calciques
/
Calcium
/
Cytokines
/
Fura-2
/
Ingénierie tissulaire
/
Médecine régénérative
/
Oestradiol
Limites du sujet:
Humans
langue:
En
Texte intégral:
Tissue Engineering and Regenerative Medicine
Année:
2016
Type:
Article