A Study of Susceptibility between Allergic Rhinitis and IL-13 Exon 4 G2044A Gene Polymorphism Study in Korean / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery
;
: 61-64, 2005.
Article
Dans Coréen
| WPRIM
| ID: wpr-650874
ABSTRACT
BACKGROUND AND OBJECTIVES:
High total serum IgE level is one of the characteristics seen in allergic rhinitis. IL-13 provides impetus to immunoglobulin class switching to IgE. The IL-13 promoter single nucleotide polymorphism has been shown to be associated with allergic diseases and abnormal IL-13 production. We tested whether a polymorphism in the coding region of IL-13 gene is associated with allergic rhinitis, blood eosinophil counts and total serum IgE levels in Korean. SUBJECTS ANDMETHOD:
Blood samples for genetic analysis were obtained from 307 individuals with allergic rhinitis and from 268 healthy subjects without atopic diseases. Polymerase chain reaction-based assay for IL-13 exon 4 G2044A was used for genotyping. Serum total IgE levels were determined by using the immunoassay. Eosinophil values were determined by eosinophil numbers per total cell numbers per microl.RESULTS:
There were no differences in the frequencies of the genotypes of IL-13 in the controls and patients (p>0.05). The frequencies of the IL-13 exon 4 2044A allele were statistically different between controls and patients (p0.05).CONCLUSION:
Our result suggests that the IL-13 exon 4 G2044A polymorphism might give susceptibility to the development of allergic rhinitis in Koreans.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Immunoglobuline E
/
Dosage immunologique
/
Numération cellulaire
/
Rhinite
/
Exons
/
Commutation de classe des immunoglobulines
/
Interleukine-13
/
Polymorphisme de nucléotide simple
/
Allèles
/
Granulocytes éosinophiles
Limites du sujet:
Humains
langue:
Coréen
Texte intégral:
Korean Journal of Otolaryngology - Head and Neck Surgery
Année:
2005
Type:
Article
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