The Effect of MPTP on Movement and TH-immunoreactive Neuronal Changes of C57BL/6 Mice in Relation to Aging / 대한해부학회지
Korean Journal of Anatomy
;
: 421-424, 1999.
Article
Dans Coréen
| WPRIM
| ID: wpr-652438
ABSTRACT
The effects of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) on movement and tyrosine hydroxylase (TH)-immunoreactive (ir) neuronal changes in young (5~6 weeks) and aged (10~12 months) C57BL/6 mice were studied. Locomotor activity was measured during 180 minutes after a single injection of 30 mg/kg of MPTP. For immunohistochemistry both young and aged mice were injected four repeated dosages of 10 mg/kg of MPTP 12 hours apart. We counted the numbers of TH-ir cell bodies using immunohistochemical technique in substantia nigra (SN), ventral tegmental area (VTA) and locus ceruleus (LC) 7 days after the last injection of MPTP. There was a marked decrease of locomotor activity in MPTP-treated young and aged mice, and a delay in recovery of locomotor activity in MPTP-treated aged mice. In young mice, there was a decrease in the number of TH-ir cell bodies in the SN of young mice, but not in VTA or LC. In aged mice, there was a significant decrease in the number of TH-ir cell bodies in VTA as well as SN. It was concluded that aged mice were more sensitive to MPTP than young mice, and MPTP-treated aged mice a more useful animal model for studing the characteristics of Parkinson's disease.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Maladie de Parkinson
/
Tyrosine 3-monooxygenase
/
Vieillissement
/
Locus ceruleus
/
Substantia nigra
/
Immunohistochimie
/
1-Méthyl-4-phényl-1,2,3,6-tétrahydropyridine
/
Aire tegmentale ventrale
/
Modèles animaux
/
Activité motrice
Type d'étude:
Étude pronostique
Limites du sujet:
Animaux
langue:
Coréen
Texte intégral:
Korean Journal of Anatomy
Année:
1999
Type:
Article
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