The Effects of Celecoxib on Wound Healing in Murine Wound Models / 대한이비인후과학회지

ABSTRACT

BACKGROUND AND OBJECTIVES: Celecoxib has suppressive effects on the growth, angiogenesis, metastasis of solid tumors including head and neck squamous cell carcinoma. Recent report suggests that celecoxib can also be usefully applied for preventing tumor recurrence in the postoperative conditions with possible residual tumors. The aim of this study is to investigate the effects of celecoxib on the post-surgical wound healing and the systems including the gastro-intestinal (GI) tracts. MATERIALS AND METHOD: Incisional and excisional wound models were created in the C3H mice and celecoxib was administered at a dose of 20 mg/kg/day to the wounded mice. Photographic documentation of the wounds was performed every week. The mice were serially sacrificed 3, 7, 14, and 28 days after wounding. The re-epithelialization and capillary number of the wounded skin were measured and the side effects of celecoxib were observed. RESULTS: Re-epithelialization was suppressed by celecoxib only in the early phase at the day 10 of wounding, which was all recovered in the late phase at day 14. The capillary number of the wounded bed was not affected by the celecoxib treatment. In addition, celecoxib had no significant side effects on the body weight change and the GI tracts of the wounded mice. CONCLUSION: This murine wound models suggest that celecoxib is a safe drug with no significant side effects to treat late wound healing or the GI tracts.