p27(Kip1) and Ki-67 Expression in Mucoepidermoid Carcinoma / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery
;
: 45-50, 2000.
Article
Dans Coréen
| WPRIM
| ID: wpr-655429
ABSTRACT
BACKGROUND AND OBJECTIVES:
p27(Kip1), novel cyclin-dependent kinase inhibitor plays an important role in the inhibition of cell cycle progression by binding to the cyclin E/cyclin-dependent kinase (CDK) 2 complex. And a nuclear antigen Ki-67, expressed in all phases of cell cycle except G0, is a reliable cellular proliferative index. The present study investigated p27(Kip1) and Ki-67 expressions in mucoepidermoid carcinoma for their usefulness of indicator in tumor progression, aggressiveness and prognosis. MATERIALS ANDMETHODS:
Formalin-fixed paraffin-embedded surgical specimens were obtained from patients with mucoepidermoid carcinoma. We performed immunohistochemical staining with p27(Kip1) and Ki-67 monoclonal antibodies and compared its labeling index with patients' clinicopathologic characteristics and survival rates.RESULTS:
There was significant correlation between low p27(Kip1), high Ki-67 expression and high grade, large tumor size, positive nodal status and high stages. Also, Ki-67 expression showed significant inverse correlation with p27(Kip1) expression and there were high survival rates in high p27(Kip1) and low Ki-67 patients.CONCLUSIONS:
Therefore, p27(Kip1) and Ki-67 are good and reliable predictive markers of tumor progression, aggressiveness and prognosis in mucoepidermoid carcinomas.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Phosphotransferases
/
Pronostic
/
Cycle cellulaire
/
Taux de survie
/
Cyclines
/
Carcinome mucoépidermoïde
/
Antigène KI-67
/
Anticorps monoclonaux
Type d'étude:
Étude pronostique
Limites du sujet:
Humains
langue:
Coréen
Texte intégral:
Korean Journal of Otolaryngology - Head and Neck Surgery
Année:
2000
Type:
Article
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