Antioxidative and Antidiarrheal Effects of Persimmon Extracts / 한국실험동물학회지
Laboratory Animal Research
;
: 407-413, 2010.
Article
Dans Coréen
| WPRIM
| ID: wpr-65551
ABSTRACT
Since oxidative stresses are involved in gastroenteritis and diarrhea, we investigated antioxidative and antidiarrheal activities of persimmon flesh extract (PFE) and persimmon calyx extract (PCE) in vitro and in vivo, respectively. PCE significantly scavenged 1,1-diphenyl-2-picrylhydrazyl hydrate and 2,2'-azinobis (3-ethylbenzthiazoline-6-sulfonic acid) from 500 microg/mL, although PFE was ineffective. In addition, PFE and PCE exhibited strong nitric oxide-scavenging effects from 1 microg/mL, in which PCE was superior to ascorbic acid (50 microM). Furthermore, PFE and PCE significantly inhibited FeCl3-induced lipid peroxidation as well as Cu2+/H2O2-induced protein oxidation from 10 microg/mL. In vivo charcoal-propulsion assay, in contrast to a negligible effect of PFE, treatment with PCE (160-500 mg/kg) markedly inhibited intestinal motility. The results indicate that extracts of persimmon, especially PCE, possess antioxidative, antiinflammatory and antidiarrheal activities. Therefore, it is suggested that persimmon extracts could be used for the relief of gastroenteritis and diarrhea.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Picrates
/
Acide ascorbique
/
Dérivés du biphényle
/
Peroxydation lipidique
/
Stress oxydatif
/
Diospyros
/
Diarrhée
/
Gastroentérite
/
Motilité gastrointestinale
langue:
Coréen
Texte intégral:
Laboratory Animal Research
Année:
2010
Type:
Article
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