Gender Differences for Long-term Prognosis in Patients With Chronic Heart Failure / 中国循环杂志

ABSTRACT

Objective: To analyze gender differences for the long-term prognosis in patients with chronic heart failure (CHF). Methods: A total of 925 consecutive CHF patients admitted in our hospital were enrolled those including 460 (49.7％) female. The mean follow-up time was 3.4 years and the end point event was all-cause mortality. Gender differences for the long-term prognosis in CHF patients were studied by Cox proportional-hazards regression analysis. Results: The overall all-cause mortality was 27.9％ during follow-up period, mortality in female was 25.2％ and in male was 30.5％. Multivariate Cox regression analysis presented that the long-term death risk in male patients was higher than female (HR=1.309, 95％ CI 1.002-1.708, P=0.048). Subgroup analysis showed that for patients age≥65 years, LVEF<45％and with NYHA grade III/IV, the long-term prognosis in female was much better than male. Conclusion: Long-term prognosis of CHF in female patients was better than male; female at age≥65 years, LVEF<45％and NYHA grade III/IV had the better prognosis.