Research Progress in β-Glucuronidase / 中国药师
China Pharmacist
;
(12): 1834-1838, 2017.
Article
Dans Chinois
| WPRIM
| ID: wpr-658118
ABSTRACT
Objective:
To summarize the structure, properties and biological functions ofβ-glucuronidase.Methods:
By referring to the relevant literatures at home and abroad onβ-glucuronidase in recent years, this paper induced, analyzed and drew conclusions.Results:
The crystal structure of humanβ-glucuronidase is comprised of three distinct structural domains. The most common mutation of β-glucuronidase is missense mutation, which results in the change of enzyme activity, and then induces a series of pathological chan-ges like MPSⅦ. The researches on β-glucuronidase used in antibody-directed enzyme prodrug drug therapy and enzyme replacement therapy are becoming deeper and deeper.Conclusion:
β-Glucuronidase as an important acid hydrolytic enzyme in human has a variety of genetic mutations, and plays an important role in the fields of medicine and disease diagnosis, which has become one of research hotspots.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
China Pharmacist
Année:
2017
Type:
Article
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