Progress of drug resistance mechanisms in acute promyelocytic leukemia / 白血病·淋巴瘤
Journal of Leukemia & Lymphoma
; (12): 637-640, 2017.
Article
de Zh
| WPRIM
| ID: wpr-659043
Bibliothèque responsable:
WPRO
ABSTRACT
Since all-trans retinoic acid (ATRA) and arsenic trioxide (As2O3) have become front-line drugs in treatment of acute promyelocytic leukemia (APL), cure rates of APL patients have improved dramatically. However, resistance to ATRA and/or As2O3has been a critical problem which has hampered the effect of treatment. In this review, some emerging mechanisms of resistance to ATRA and/or As2O3in recent years, such as genetic mutations, disorders of cellular signal transduction, disorders of chromatin remodeling complex, abnormal regulation of cell apoptosis, and micro-environment mediated drug resistance are summarized.
Texte intégral:
1
Indice:
WPRIM
langue:
Zh
Texte intégral:
Journal of Leukemia & Lymphoma
Année:
2017
Type:
Article