The expression of HOXD10 protein in colorectal cancer and its clinical significance / 实用医学杂志

ABSTRACT

Objective To investigate the expressions of homeobox gene 10 (HOXD10) and analyze its clinical significance. Methods Expressions of HOXD10 protein was detected by immunohistochemistry SP method in 53 cases of colorectal carcinoma tissues and corresponding normal tissues which was fixed by 4% formalin and embedded by paraffin.It was analyzed that the relationship between the expression of HOXD10 protein and clinico-pathological features. Results The positive staining rate of HOXD10 protein in normal colorectal mucosal tissue (5.7%)was significantly lower than that incolorectal carcinoma tissue(64.2%),the difference was statistically sig-nificant(P<0.05). In colorectal cancer tissue,the positive rate of HOXD10 protein in high differentiation(53.8%), T1+T2(38.5%),Ⅰ+Ⅱ(54.3%)and no lymph node metastasis(55.3%)was lower than that in low differentiation (73.0%),T3+T4(72.5%),Ⅲ+Ⅳ(83.3%)and lymph node metastasis,the difference was statistically significant (P < 0.05). However,it was not statistically significant between the positive rate of HOXD10 protein and the gender,age,primary site and tumor size in colorectal cancer patients(P>0.05). Conclusion The expression of HOXD10 protein is closely related to the invasion and metastasis of colorectal cancer.