Influence of hydrochlorothiazide combined valsartan on therapeutic effects,cardiac function and levels of serum RBP4,Vaspin in hypertension patients / 心血管康复医学杂志

ABSTRACT

Objective:To study therapeutic effects of hydrochlorothiazide combined valsartan on aged patients with essential hypertension (EH),and its influence on cardiac function,serum levels of retinol-binding protein 4 (RBP4) and visceral adipose tissue-derived serine protease inhibitor (Vaspin).Methods:A total of 148 aged EH patients treated in our hospital from Dec 2014 to Dec 2015 were selected.According to random number table,patients were randomly and equally divided into valsartan group and combined treatment group (received hydrochlorothiazide therapy based on valsartan group).Blood pressure,left ventricular mass (LVM),left ventricular mass index (LV-MI),serum RBP4 and Vaspin levels before and after treatment were compared between two groups.Results:Com-pared with valsartan group after six-month treatment,there were significant reductions in levels of systolic blood pressure[(154.35±11.64)mmHg vs.(138.37±12.85)mmHg],diastolic blood pressure[(98.68±9.97)mmHg vs. (80.35±8.57)mmHg],LVM[(204.75 ± 12.35 )g vs.(198.77 ± 12.64)g],LVMI [(128.68 ± 6.54)g/m2 vs. (118.35±5.74)g/m2 ]and serum RBP4 level [(26.56±5.67)g/ml vs.(24.75±5.36)g/ml],and significant rise in serum Vaspin level [(10.23 ± 1.10)pg/ml vs.(12.43 ± 1.12)pg/ml]in combined treatment group,P < 0.01 all. Compared with valsartan group,there was significant rise in total effective rate (64.8% vs.82.4%,P =0.015)in combined treatment group.Conclusion:Hydrochlorothiazide combined valsartan can significantly reduce blood pres-sure and serum RBP4 level,significantly increase Vaspin level in aged EH patients,which is worth extending.