Amyotrophic lateral sclerosis-associated gene mutations and ALS animal models / 中国比较医学杂志
Chinese Journal of Comparative Medicine
; (6): 89-95, 2017.
Article
de Zh
| WPRIM
| ID: wpr-660920
Bibliothèque responsable:
WPRO
ABSTRACT
Amyotrophic lateral sclerosis ( ALS ) is a progressive neurodegenerative disease characterized by a selective loss of upper and lower motor neurons that lead to paralysis and even death. Mutations in a large number of genes, including FUS/TLS, EPHA4, SS18 L1, ATXN2 and C9ORF72, are identified to the casual genes of ALS, which broadens our understanding of the role of RNA modulation in ALS pathogenesis. This review summarized ALS-associated genes and the related ALS rodent models.
Texte intégral:
1
Indice:
WPRIM
langue:
Zh
Texte intégral:
Chinese Journal of Comparative Medicine
Année:
2017
Type:
Article