Percutaneous Embolization Using Histoacrylic Blue(N-butyl 2-cyanoacrylate) in VX-2 Carcinoma in the Orbit of Rabbits

ABSTRACT

PURPOSE: To investigate the efficacy of percutaneous embolization of hypervascular VX-2 carcinoma in the retroorbital area of the rabbits using Histoacrylic Blue(N-butyl 2-cyanoacrylate, NBCA) and to establish as an experimental model. MATERIALS AND METHODS: Retroorbital VX-2 carcinoma was made in 10 rabbits by injection of carcioma cells. At 2 and 4 weeks following the tumor cell injection, carotid angiography was performed before and after percutaneous embolization using 50% NBCA diluted with Lipiodol. Doppler ultrasonography was also performed to evaluate the vascularity of the mass. Light microscopic examination was used to evaluate the effect of embolization on the tumor mass. RESULTS: Angiography following percutaneous embolization showed filling of embolic materials in the tumor beds. Ultrasonographic findings showed tumor necrosis and increased Doppler signal in the tumor. Histopathological examinations showed extensive necrosis of tumor cells with remaining viable cells surrounding the capillaries. There were no NBCA emboli in arterioles and capillaries of tumor beds in multiple sections. CONCLUSION: Since 50% diluted NBCA used as percutaneous embolus into the retroorbital VX-2 carcinoma dose not get into small blood vessels of tumor beds. using NBCA in lower concentration in the hypervascular tumor would be the next step to figure out its usefulness. This study also serves as an experimental model of percutaneous embolization of hypervascular tumor.