Research progress on neuroprotective effect and mechanism of salidroside / 药物评价研究
Drug Evaluation Research
;
(6): 1019-1028, 2017.
Article
Dans Chinois
| WPRIM
| ID: wpr-662849
ABSTRACT
Some animal model experiments have found that salidroside has protective effect for injuries in various neurons and brain tissue induced by various causes,so it is expected to be used in the prevention and treatment of peripheral nerve injury,and cerebral ischemic and neurodegenerative diseases,such as cerebral infarction,Alzheimer's disease,Parkinson's disease,epilepsy,depression,Tourette syndrome,amyotrophic lateral sclerosis,and diabetic encephalopathy.Its mechanisms of neuroprotection are multiple(1) Salidroside protects neurons and stem cells from apoptotic injury by antioxidation,blocking NOX2/ROS/MAPKs and REDD 1/mTOR/p70S6K signaling pathways,and promoting AMPK/SIRT1,RhoA-MAPK and PI3K/Akt signaling pathways against various injurious factors-induced oxidative stress,inhibiting expression of inflammatory cytokines,preventing intracellular Ca2+ overload and caspase-3 activation;(2) Salidroside obstructs endogenous amyloid-β production by inhibition of expression of β-site amyloid precursor protein cleaving enzyme 1 and β-secretase activity.(3) Salidroside accelerates repair,regeneration and functional recovery of nerve by block Notch signaling pathway,and promoting BMP signaling pathway,super-regulating expression of neurotrophic factors,inducing neural stem cells and mesenchymal stem cells to differentiate into neural cells,and improving proliferation and function of Schwann cells.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Type d'étude:
Étude pronostique
langue:
Chinois
Texte intégral:
Drug Evaluation Research
Année:
2017
Type:
Article
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