Association of the polymorphisms in TP63 rs6790167 with risk for lung cancer in Hain-an Han population / 中国肿瘤临床

ABSTRACT

Objective:To evaluate the association between the polymorphisms in TP63 rs6790167 and lung cancer. Methods:We per-formed a case-control study with 258 patients and 270 controls. Genomic DNA was extracted using a blood genome extraction kit. Ge-notyping was conducted using allele-specific polymerase chain reaction (AS-PCR). Results:No significant difference was observed in the genotype of TP63 rs6790167 between cases and controls, and allele frequencies significantly elevated in the cases (P=0.045). In a further stratified analysis by gender and smoking status, the frequencies of the GG genotype and G allele of rs6790167 were signifi-cantly higher in non-smoking male patients with lung adenocarcinoma (P=0.000, P=0.001), individuals with GG genotype had a higher risk for lung adenocarcinoma in non-smoking man (OR=6.66, 95%CI2.16-20.41). Individuals with G allele had a higher risk for lung ad-enocarcinoma in a non-smoking man (OR=2.54, 95%CI1.42-4.56) in comparison with individuals with A allele. Conclusion:We found that the polymorphisms of TP63 rs6790167 were associated with the risk for lung adenocarcinoma in non-smoking men and that these polymorphisms may be a predictor for lung adenocarcinoma in non-smoking men.