Advances in the HIF-1α/p300 protein-protein interaction inhibitors / 中国药科大学学报
Journal of China Pharmaceutical University
; (6): 515-522, 2017.
Article
de Zh
| WPRIM
| ID: wpr-664282
Bibliothèque responsable:
WPRO
ABSTRACT
Hypoxia induced factor-1 α (HIF-1α) is a key regulation factor that helps tumor adapt itself to the hypoxia microenvironment.It regulates the expression of more than 100 target genes that control cell proliferation and survival,metabolism,angiogenesis,invasion and metastasis.HIF-1α/p300,a core complex that regulates downstream genes expression,is considered as a potential antitumor target.This review summarizes HIF-1 α signal pathway,the binding mode of HIF-1α/p300 protein-protein interaction and recent development on the HIF-1α/ p300 protein-protein interaction inhibitors,which provides reference to the design of this kind of inhibitors.
Texte intégral:
1
Indice:
WPRIM
langue:
Zh
Texte intégral:
Journal of China Pharmaceutical University
Année:
2017
Type:
Article