Preoperative planning of laparoscopic ultrasound-guided I125 implantation in treatment of pancreatic cancer based on CT images / 中国介入影像与治疗学

ABSTRACT

Objective To propose a novel preoperative planning method for laparoscopic ultrasound-guided implantation of I125 seeds in treating pancreatic cancer based on CT images,and to evaluate the feasibility of this treatment.Methods CT images of a pancreatic cancer patient were transmitted into the treatment planning system (TPS) developed by our laboratory,to obtain three-dimensional representations of the tumor and surrounding organs.All the positions of puncture were selected with the aid of virtual template,then possible needle paths and the number of necessary I125 seeds were planned,and the radiation dose was evaluated.Results A total of 21 needle paths with 45 seeds implantation into the tumor were planned.In the preoperative planning,the dosage parameters D90 and V100 of the tumor were 12 481 cGy and 92.83％,which was relatively eligible for the clinic requirement,whereas of suurounding non-tumor pancreatic tissue was 0 and 0.40％,respecyively.Conclusion Laparoscopic ultrasound-guided implantation of I125 seeds can be considered as a useful method for treating pancreatic cancer with accurate implantation of 125I seeds and satisfying effect of local control for the tumor in theory.