Pyroptosis and eye disease / 中华实验眼科杂志

ABSTRACT

Pyroptosis is a new programmed cell death which has been found recently.Pyroptosis features rapid plasma-membrane rupture and release of pro-inflammatory intracellular contents.Pyroptosis plays a vital role in intracellular bacterial clearance,but may also be involved in the pathological process of inflammatory and autoimmune diseases.It exists in the occurrence,development and dying of many eye diseases.The researches of pyroptosis in agerelated macular degeneration (AMD),cataract,dry eye disease,Mooren's ulcer and acute glaucoma have emerged,an in-depth research may be useful in understanding eye diseases in a deeper level.In this artile,the concept of pyroptosis and its involvement in AMD,cataract,dry eye disease,Mooren's ulcer and acute glaucoma are reviewed.